Prediction of Peak Serum Vancomycin Levels from Trough Values in Neonates 1438

Dose regimen for vancomycin not needing serum peak levels?

AIM To determine the safety, efficacy, and need to measure peak serum vancomycin concentrations in a neonatal population using a standard vancomycin dosage regimen. METHOD A total of 101 infants who were admitted to a regional neonatal intensive care unit and received vancomycin (15 mg/kg every 12 or 18 hours depending on postnatal age) were studied retrospectively. Infants who had been start...

Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates

Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancom...

Vancomycin Trough Levels: Cause or Result of Acute Kidney Injury?

clearance of vancomycin to the clearance of the gold standard glomerular filtration rate (GFR) marker inulin is 0.89 in normal volunteers at steady state with endogenous creatinine as a filtration marker the ratio is 0.79 [5] . Therefore, the vancomycin clearance is a better GFR marker than is the creatinine clearance. Thus the interpretation of trough levels needs to be based on the renal func...

Serum cystatin C predicts vancomycin trough levels better than serum creatinine in hospitalized patients: a cohort study

INTRODUCTION Serum cystatin C can improve glomerular filtration rate (GFR) estimation over creatinine alone, but whether this translates into clinically relevant improvements in drug dosing is unclear. METHODS This prospective cohort study enrolled adults receiving scheduled intravenous vancomycin while hospitalized at the Mayo Clinic in 2012. Vancomycin dosing was based on weight, serum crea...

Peak and Trough.